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MILLS, GORDON B
One or more keywords matched the following items that are connected to MILLS, GORDON B
Item TypeName
Academic Article Heregulin-induced apoptosis is mediated by down-regulation of Bcl-2 and activation of caspase-7 and is potentiated by impairment of protein kinase C alpha activity.
Academic Article A retrovirus-based protein complementation assay screen reveals functional AKT1-binding partners.
Academic Article Atypical PKCiota contributes to poor prognosis through loss of apical-basal polarity and cyclin E overexpression in ovarian cancer.
Academic Article The Akt inhibitor KP372-1 inhibits proliferation and induces apoptosis and anoikis in squamous cell carcinoma of the head and neck.
Academic Article BSTA promotes mTORC2-mediated phosphorylation of Akt1 to suppress expression of FoxC2 and stimulate adipocyte differentiation.
Academic Article A plant triterpenoid, avicin D, induces autophagy by activation of AMP-activated protein kinase.
Academic Article Dual targeting of AKT and mammalian target of rapamycin: a potential therapeutic approach for malignant peripheral nerve sheath tumor.
Academic Article The Akt inhibitor KP372-1 suppresses Akt activity and cell proliferation and induces apoptosis in thyroid cancer cells.
Academic Article Integrin-linked kinase is a potential therapeutic target for anaplastic thyroid cancer.
Academic Article Akt inhibitor shows anticancer and radiosensitizing effects in malignant glioma cells by inducing autophagy.
Academic Article Proteomic and transcriptomic profiling reveals a link between the PI3K pathway and lower estrogen-receptor (ER) levels and activity in ER+ breast cancer.
Academic Article High frequency of PIK3R1 and PIK3R2 mutations in endometrial cancer elucidates a novel mechanism for regulation of PTEN protein stability.
Academic Article Roles of genetic variants in the PI3K and RAS/RAF pathways in susceptibility to endometrial cancer and clinical outcomes.
Concept Protein Kinase C
Concept DNA-Activated Protein Kinase
Concept CDC2 Protein Kinase
Concept Protein Kinase Inhibitors
Concept Mitogen-Activated Protein Kinase 1
Concept Protein Kinase C-alpha
Concept Mitogen-Activated Protein Kinase Kinases
Concept Calcium-Calmodulin-Dependent Protein Kinase Type 2
Concept Mitogen-Activated Protein Kinase 3
Concept Mitogen-Activated Protein Kinase Phosphatases
Concept Proto-Oncogene Proteins c-akt
Academic Article HER2/PI-3K/Akt activation leads to a multidrug resistance in human breast adenocarcinoma cells.
Academic Article Comprehensive molecular characterization of clear cell renal cell carcinoma.
Academic Article Kinome siRNA-phosphoproteomic screen identifies networks regulating AKT signaling.
Academic Article Comprehensive molecular characterization of urothelial bladder carcinoma.
Academic Article Coordinate phosphorylation of multiple residues on single AKT1 and AKT2 molecules.
Academic Article Definition of PKC-a, CDK6, and MET as therapeutic targets in triple-negative breast cancer.
Academic Article Association between germline single nucleotide polymorphisms in the PI3K-AKT-mTOR pathway, obesity, and breast cancer disease-free survival.
Academic Article Overcoming endocrine resistance due to reduced PTEN levels in estrogen receptor-positive breast cancer by co-targeting mammalian target of rapamycin, protein kinase B, or mitogen-activated protein kinase kinase.
Academic Article A comprehensive evaluation of biomarkers predictive of response to PI3K inhibitors and of resistance mechanisms in head and neck squamous cell carcinoma.
Academic Article Genetic events that limit the efficacy of MEK and RTK inhibitor therapies in a mouse model of KRAS-driven pancreatic cancer.
Academic Article Transmembrane ion fluxes during activation of human T lymphocytes: role of Ca2+, Na+/H+ exchange and phospholipid turnover.
Academic Article Regulation of BAD phosphorylation at serine 112 by the Ras-mitogen-activated protein kinase pathway.
Academic Article Phosphorylation and inactivation of glycogen synthase kinase 3 by protein kinase A.
Academic Article XIAP regulates Akt activity and caspase-3-dependent cleavage during cisplatin-induced apoptosis in human ovarian epithelial cancer cells.
Academic Article Expression of CD26 and its associated dipeptidyl peptidase IV enzyme activity enhances sensitivity to doxorubicin-induced cell cycle arrest at the G(2)/M checkpoint.
Academic Article Insulin-like growth factor-I inhibits progesterone receptor expression in breast cancer cells via the phosphatidylinositol 3-kinase/Akt/mammalian target of rapamycin pathway: progesterone receptor as a potential indicator of growth factor activity in breast cancer.
Academic Article Determinants of rapamycin sensitivity in breast cancer cells.
Academic Article The RAB25 small GTPase determines aggressiveness of ovarian and breast cancers.
Academic Article Synergistic augmentation of rapamycin-induced autophagy in malignant glioma cells by phosphatidylinositol 3-kinase/protein kinase B inhibitors.
Academic Article An inherent role of integrin-linked kinase-estrogen receptor alpha interaction in cell migration.
Academic Article Acquired resistance to erlotinib in A-431 epidermoid cancer cells requires down-regulation of MMAC1/PTEN and up-regulation of phosphorylated Akt.
Academic Article Pharmacodynamic markers of perifosine efficacy.
Academic Article AMP-activated protein kinase signaling results in cytoplasmic sequestration of p27.
Academic Article Vimentin is a novel AKT1 target mediating motility and invasion.
Academic Article Inhibition of c-Met downregulates TIGAR expression and reduces NADPH production leading to cell death.
Academic Article MYC pathway activation in triple-negative breast cancer is synthetic lethal with CDK inhibition.
Academic Article Profiling of residual breast cancers after neoadjuvant chemotherapy identifies DUSP4 deficiency as a mechanism of drug resistance.
Academic Article Self-reinforcing loop of amphiregulin and Y-box binding protein-1 contributes to poor outcomes in ovarian cancer.
Academic Article Small molecule ErbB inhibitors decrease proliferative signaling and promote apoptosis in philadelphia chromosome-positive acute lymphoblastic leukemia.
Academic Article Expression of TTK, a novel human protein kinase, is associated with cell proliferation.
Academic Article Antigen-induced Fc receptor-dependent and -independent B cell desensitization. An elevation in [Ca2+]i is not sufficient and protein kinase C activation is not required for these pathways of surface IgM-mediated desensitization.
Academic Article Expression of ras oncogene leads to down-regulation of protein kinase C.
Academic Article Inhibition of stimulus-dependent epidermal growth factor receptor and transforming growth factor-alpha mRNA accumulation by the protein kinase C inhibitor staurosporine.
Academic Article The diacylglycerol analogue, 1,2-sn-dioctanoylglycerol, induces an increase in cytosolic free Ca2+ and cytosolic acidification of T lymphocytes through a protein kinase C-independent process.
Academic Article The cell biology of ras-induced transformation: insights from studies utilizing an inducible hybrid oncogene system.
Academic Article Osmotic activation of the Na+/H+ antiport in protein kinase C-depleted lymphocytes.
Academic Article The SH3 domain of Itk/Emt binds to proline-rich sequences in the cytoplasmic domain of the T cell costimulatory receptor CD28.
Academic Article Adenoviral transgene expression of MMAC/PTEN in human glioma cells inhibits Akt activation and induces anoikis.
Academic Article Inhibition of growth-factor-induced phosphorylation and activation of protein kinase B/Akt by atypical protein kinase C in breast cancer cells.
Academic Article Sustained activation of JNK/p38 MAPK pathways in response to cisplatin leads to Fas ligand induction and cell death in ovarian carcinoma cells.
Academic Article Evidence that phosphatidylinositol 3-kinase- and mitogen-activated protein kinase kinase-4/c-Jun NH2-terminal kinase-dependent Pathways cooperate to maintain lung cancer cell survival.
Academic Article Inhibition of phosphatidylinositol 3-kinase dephosphorylates BAD and promotes apoptosis in myeloid leukemias.
Academic Article Glycogen synthase kinase 3beta is a negative regulator of growth factor-induced activation of the c-Jun N-terminal kinase.
Academic Article mTOR inhibition induces upstream receptor tyrosine kinase signaling and activates Akt.
Academic Article Inhibition of Akt survival pathway by a small-molecule inhibitor in human glioblastoma.
Academic Article Autophosphorylation of Akt at threonine 72 and serine 246. A potential mechanism of regulation of Akt kinase activity.
Academic Article The energy sensing LKB1-AMPK pathway regulates p27(kip1) phosphorylation mediating the decision to enter autophagy or apoptosis.
Academic Article Soft tissue sarcoma cells are highly sensitive to AKT blockade: a role for p53-independent up-regulation of GADD45 alpha.
Academic Article Mutations in the phosphatidylinositol-3-kinase pathway predict for antitumor activity of the inhibitor PX-866 whereas oncogenic Ras is a dominant predictor for resistance.
Academic Article Akt1 and akt2 play distinct roles in the initiation and metastatic phases of mammary tumor progression.
Academic Article Activity of dasatinib against L576P KIT mutant melanoma: molecular, cellular, and clinical correlates.
Academic Article Reciprocal regulation of c-Src and STAT3 in non-small cell lung cancer.
Academic Article Arsenic trioxide induces a beclin-1-independent autophagic pathway via modulation of SnoN/SkiL expression in ovarian carcinoma cells.
Academic Article Hyperactivation of phosphatidylinositol-3 kinase promotes escape from hormone dependence in estrogen receptor-positive human breast cancer.
Academic Article Steroid receptor coactivator-3 expression in lung cancer and its role in the regulation of cancer cell survival and proliferation.
Academic Article Activation of murine double minute 2 by Akt in mammary epithelium delays mammary involution and accelerates mammary tumorigenesis.
Academic Article Proteomic profiling identifies pathways dysregulated in non-small cell lung cancer and an inverse association of AMPK and adhesion pathways with recurrence.
Academic Article Phosphoproteomic mass spectrometry profiling links Src family kinases to escape from HER2 tyrosine kinase inhibition.
Academic Article MDA-7 results in downregulation of AKT concomitant with apoptosis and cell cycle arrest in breast cancer cells.
Academic Article PIK3CA/PTEN mutations and Akt activation as markers of sensitivity to allosteric mTOR inhibitors.
Academic Article Biomarkers of response to Akt inhibitor MK-2206 in breast cancer.
Academic Article Resistance to BRAF inhibition in BRAF-mutant colon cancer can be overcome with PI3K inhibition or demethylating agents.
Academic Article Site-specific activation of AKT protects cells from death induced by glucose deprivation.
Academic Article AMPK: a contextual oncogene or tumor suppressor?
Academic Article Clinical investigation of receptor and non-receptor tyrosine kinase inhibitors for the treatment of epithelial ovarian cancer.
Academic Article Role of protein kinase C in interleukin 1, anti-T3, and mitogenic lectin-induced interleukin 2 secretion.
Academic Article Interleukin-2 induces proliferation of T lymphocyte mutants lacking protein kinase C.
Academic Article Interleukin 2 activates a receptor-associated protein kinase.
Academic Article Interleukin-2 secretion and transmembrane signalling in burned patients.
Academic Article Induction of competence and progression signals in human T lymphocytes by phorbol esters and calcium ionophores.
Academic Article Expression of human tyrosine kinase-negative epidermal growth factor receptor amplifies signaling through endogenous murine epidermal growth factor receptor.
Academic Article Cell cycle dependent regulation of the protein kinase TTK.
Academic Article Lysophosphatidylcholine stimulates activator protein 1 and the c-Jun N-terminal kinase activity.
Academic Article Lysophosphatidic acid prevents apoptosis in fibroblasts via G(i)-protein-mediated activation of mitogen-activated protein kinase.
Academic Article Inhibition of the phosphatidylinositol 3'-kinase-AKT pathway induces apoptosis in pancreatic carcinoma cells in vitro and in vivo.
Academic Article Effect of CD26/dipeptidyl peptidase IV on Jurkat sensitivity to G2/M arrest induced by topoisomerase II inhibitors.
Academic Article Targeting the phosphatidylinositol 3-kinase/Akt pathway for enhancing breast cancer cells to radiotherapy.
Academic Article Targeting PI3K-AKT pathway for cancer therapy.
Academic Article Mammalian target of rapamycin.
Academic Article Structure-activity relationships of fluorinated lysophosphatidic acid analogues.
Academic Article G-CSF induced reactive oxygen species involves Lyn-PI3-kinase-Akt and contributes to myeloid cell growth.
Academic Article Inhibition of the phosphatidylinositol-3 kinase/Akt promotes G1 cell cycle arrest and apoptosis in Hodgkin lymphoma.
Academic Article Phosphorylation of TNF-alpha converting enzyme by gastrin-releasing peptide induces amphiregulin release and EGF receptor activation.
Academic Article Cytoplasmic expression of p21CIP1/WAF1 is correlated with IKKbeta overexpression in human breast cancers.
Academic Article Point mutations of protein kinases and individualised cancer therapy.
Academic Article A new mutational AKTivation in the PI3K pathway.
Academic Article An integrative genomic and proteomic analysis of PIK3CA, PTEN, and AKT mutations in breast cancer.
Academic Article A novel AKT3 mutation in melanoma tumours and cell lines.
Academic Article Characterization of a naturally occurring breast cancer subset enriched in epithelial-to-mesenchymal transition and stem cell characteristics.
Academic Article Combined Src and aromatase inhibition impairs human breast cancer growth in vivo and bypass pathways are activated in AZD0530-resistant tumors.
Academic Article Physical association of PDK1 with AKT1 is sufficient for pathway activation independent of membrane localization and phosphatidylinositol 3 kinase.
Academic Article PIK3CA mutations associated with gene signature of low mTORC1 signaling and better outcomes in estrogen receptor-positive breast cancer.
Academic Article Identification of optimal drug combinations targeting cellular networks: integrating phospho-proteomics and computational network analysis.
Academic Article Activation of p21(CIP1/WAF1) in mammary epithelium accelerates mammary tumorigenesis and promotes lung metastasis.
Academic Article Deciphering the role of PI3K/Akt/mTOR pathway in breast cancer biology and pathogenesis.
Academic Article Two phases of mitogenic signaling unveil roles for p53 and EGR1 in elimination of inconsistent growth signals.
Academic Article Akt and ERK control the proliferative response of mammary epithelial cells to the growth factors IGF-1 and EGF through the cell cycle inhibitor p57Kip2.
Academic Article AKT-dependent phosphorylation of Niban regulates nucleophosmin- and MDM2-mediated p53 stability and cell apoptosis.
Academic Article An epithelial-mesenchymal transition gene signature predicts resistance to EGFR and PI3K inhibitors and identifies Axl as a therapeutic target for overcoming EGFR inhibitor resistance.
Academic Article Frequent mutation of the PI3K pathway in head and neck cancer defines predictive biomarkers.
Academic Article A genetic mouse model of invasive endometrial cancer driven by concurrent loss of Pten and Lkb1 Is highly responsive to mTOR inhibition.
Academic Article Physiologic activation of protein kinase C limits IL-2 secretion.
Academic Article CD28-mediated cytotoxicity by the human leukemic NK cell line YT involves tyrosine phosphorylation, activation of phosphatidylinositol 3-kinase, and protein kinase C.
Academic Article Protein kinase B (PKB/Akt) activity is elevated in glioblastoma cells due to mutation of the tumor suppressor PTEN/MMAC.
Academic Article Convergence of multiple signaling cascades at glycogen synthase kinase 3: Edg receptor-mediated phosphorylation and inactivation by lysophosphatidic acid through a protein kinase C-dependent intracellular pathway.
Academic Article Linking molecular diagnostics to molecular therapeutics: targeting the PI3K pathway in breast cancer.
Academic Article Genes affecting the cell cycle, growth, maintenance, and drug sensitivity are preferentially regulated by anti-HER2 antibody through phosphatidylinositol 3-kinase-AKT signaling.
Academic Article Targeting integrin-linked kinase inhibits Akt signaling pathways and decreases tumor progression of human glioblastoma.
Academic Article Differential roles of phosphoinositide-dependent protein kinase-1 and akt1 expression and phosphorylation in breast cancer cell resistance to Paclitaxel, Doxorubicin, and gemcitabine.
Academic Article Activation of integrin-linked kinase is a critical prosurvival pathway induced in leukemic cells by bone marrow-derived stromal cells.
Academic Article Network topology determines dynamics of the mammalian MAPK1,2 signaling network: bifan motif regulation of C-Raf and B-Raf isoforms by FGFR and MC1R.
Academic Article Intratumoral epidermal growth factor receptor antisense DNA therapy in head and neck cancer: first human application and potential antitumor mechanisms.
Academic Article PTEN deficiency is fully penetrant for prostate adenocarcinoma in C57BL/6 mice via mTOR-dependent growth.
Academic Article DNA-PK mediates AKT activation and apoptosis inhibition in clinically acquired platinum resistance.
Academic Article Dissecting "PI3Kness": the complexity of personalized therapy for ovarian cancer.
Academic Article Network analysis of the focal adhesion to invadopodia transition identifies a PI3K-PKCa invasive signaling axis.
Academic Article Activation and interaction with protein kinase C of a cytoplasmic tyrosine kinase, Itk/Tsk/Emt, on Fc epsilon RI cross-linking on mast cells.
Academic Article Activation of the ras-mitogen-activated protein kinase pathway and phosphorylation of ets-2 at position threonine 72 in human ovarian cancer cell lines.
Academic Article Src family protein-tyrosine kinases alter the function of PTEN to regulate phosphatidylinositol 3-kinase/AKT cascades.
Academic Article Enantioselective responses to a phosphorothioate analogue of lysophosphatidic acid with LPA3 receptor-selective agonist activity.
Academic Article Exploiting the PI3K/AKT pathway for cancer drug discovery.
Academic Article Simultaneous inhibition of PDK1/AKT and Fms-like tyrosine kinase 3 signaling by a small-molecule KP372-1 induces mitochondrial dysfunction and apoptosis in acute myelogenous leukemia.
Academic Article Phosphorylation of beta-catenin by AKT promotes beta-catenin transcriptional activity.
Academic Article Src promotes estrogen-dependent estrogen receptor alpha proteolysis in human breast cancer.
Academic Article Basal subtype and MAPK/ERK kinase (MEK)-phosphoinositide 3-kinase feedback signaling determine susceptibility of breast cancer cells to MEK inhibition.
Academic Article AKT-independent signaling downstream of oncogenic PIK3CA mutations in human cancer.
Academic Article Functional proteomics characterization of residual triple-negative breast cancer after standard neoadjuvant chemotherapy.
Academic Article A functional proteogenomic analysis of endometrioid and clear cell carcinomas using reverse phase protein array and mutation analysis: protein expression is histotype-specific and loss of ARID1A/BAF250a is associated with AKT phosphorylation.
Academic Article Targeting tyrosine-kinases and estrogen receptor abrogates resistance to endocrine therapy in breast cancer.
Academic Article AKT pathway genes define 5 prognostic subgroups in glioblastoma.
Academic Article The RAC1 P29S hotspot mutation in melanoma confers resistance to pharmacological inhibition of RAF.
Academic Article Next generation sequencing analysis of platinum refractory advanced germ cell tumor sensitive to Sunitinib (Sutent?) a VEGFR2/PDGFR?/c-kit/ FLT3/RET/CSF1R inhibitor in a phase II trial.
Academic Article PIK3CA mutations in androgen receptor-positive triple negative breast cancer confer sensitivity to the combination of PI3K and androgen receptor inhibitors.
Academic Article Integrated analysis of transcriptomes of cancer cell lines and patient samples reveals STK11/LKB1-driven regulation of cAMP phosphodiesterase-4D.
Academic Article Catalytic mTOR inhibitors can overcome intrinsic and acquired resistance to allosteric mTOR inhibitors.
Academic Article Loss of progesterone receptor links to high proliferation and increases from primary to metastatic endometrial cancer lesions.
Academic Article P-REX1 creates a positive feedback loop to activate growth factor receptor, PI3K/AKT and MEK/ERK signaling in breast cancer.
Academic Article Inhibition of mTORC1/2 overcomes resistance to MAPK pathway inhibitors mediated by PGC1a and oxidative phosphorylation in melanoma.
Academic Article LYN-activating mutations mediate antiestrogen resistance in estrogen receptor-positive breast cancer.
Academic Article Co-clinical assessment identifies patterns of BRAF inhibitor resistance in melanoma.
Academic Article Feasibility of Large-Scale Genomic Testing to Facilitate Enrollment Onto Genomically Matched Clinical Trials.
Academic Article Co-occurring genomic alterations define major subsets of KRAS-mutant lung adenocarcinoma with distinct biology, immune profiles, and therapeutic vulnerabilities.
Academic Article Death-associated protein kinase 1 promotes growth of p53-mutant cancers.
Academic Article Genomic Correlate of Exceptional Erlotinib Response in Head and Neck Squamous Cell Carcinoma.
Academic Article Decoupling of the PI3K Pathway via Mutation Necessitates Combinatorial Treatment in HER2+ Breast Cancer.
Academic Article The PI3K/AKT Pathway and Renal Cell Carcinoma.
Academic Article A putative biomarker signature for clinically effective AKT inhibition: correlation of in vitro, in vivo and clinical data identifies the importance of modulation of the mTORC1 pathway.
Academic Article mTOR Inhibitors Suppress Homologous Recombination Repair and Synergize with PARP Inhibitors via Regulating SUV39H1 in BRCA-Proficient Triple-Negative Breast Cancer.
Academic Article Multilevel Genomics-Based Taxonomy of Renal Cell Carcinoma.
Academic Article Analysis of phosphatases in ER-negative breast cancers identifies DUSP4 as a critical regulator of growth and invasion.
Academic Article Multiplatform-based molecular subtypes of non-small-cell lung cancer.
Academic Article Cell cycle dependent regulation of the protein kinase TTK
Academic Article Phosphorylation of the IL2 receptor involves an inducible protein kinase
Academic Article A Pan-Cancer Proteogenomic Atlas of PI3K/AKT/mTOR Pathway Alterations.
Academic Article Rational combination therapy with PARP and MEK inhibitors capitalizes on therapeutic liabilities in RAS mutant cancers.
Academic Article PKCiota promotes ovarian tumor progression through deregulation of cyclin E.
Academic Article Personalized Preclinical Trials in BRAF Inhibitor-Resistant Patient-Derived Xenograft Models Identify Second-Line Combination Therapies.
Academic Article Cardiac glycosides display selective efficacy for STK11 mutant lung cancer.
Academic Article Targeting mitochondrial biogenesis to overcome drug resistance to MAPK inhibitors.
Academic Article Loss of ARID1A Activates ANXA1, which Serves as a Predictive Biomarker for Trastuzumab Resistance.
Academic Article Targeting of PYK2 Synergizes with EGFR Antagonists in Basal-like TNBC and Circumvents HER3-Associated Resistance via the NEDD4-NDRG1 Axis.
Academic Article YAP/TAZ-Mediated Upregulation of GAB2 Leads to Increased Sensitivity to Growth Factor-Induced Activation of the PI3K Pathway.
Academic Article ERK and p38 MAPK Activities Determine Sensitivity to PI3K/mTOR Inhibition via Regulation of MYC and YAP.
Academic Article PAK signalling drives acquired drug resistance to MAPK inhibitors in BRAF-mutant melanomas.
Academic Article PIK3CA exon9 mutations associate with reduced survival, and are highly concordant between matching primary tumors and metastases in endometrial cancer.
Academic Article Microenvironment-Mediated Mechanisms of Resistance to HER2 Inhibitors Differ between HER2+ Breast Cancer Subtypes.
Academic Article EGFR-Phosphorylated Platelet Isoform of Phosphofructokinase 1 Promotes PI3K Activation.
Academic Article Co-targeting BET and MEK as salvage therapy for MAPK and checkpoint inhibitor-resistant melanoma.
Academic Article Survival of Cancer Stem-Like Cells Under Metabolic Stress via CaMK2a-mediated Upregulation of Sarco/Endoplasmic Reticulum Calcium ATPase Expression.
Academic Article Preclinical evaluation and reverse phase protein Array-based profiling of PI3K and MEK inhibitors in endometrial carcinoma in vitro.
Academic Article ?-catenin/TCF activity regulates IGF-1R tyrosine kinase inhibitor sensitivity in colon cancer.
Academic Article Dual Src and MEK Inhibition Decreases Ovarian Cancer Growth and Targets Tumor Initiating Stem-Like Cells.
Academic Article Defective Replication Stress Response Is Inherently Linked to the Cancer Stem Cell Phenotype.
Academic Article Deregulated Gab2 phosphorylation mediates aberrant AKT and STAT3 signaling upon PIK3R1 loss in ovarian cancer.
Academic Article Loss of Phd2 cooperates with BRAFV600E to drive melanomagenesis.
Academic Article Neomorphic PDGFRA extracellular domain driver mutations are resistant to PDGFRA targeted therapies.
Academic Article PIK3CA Amplification Associates with Aggressive Phenotype but Not Markers of AKT-MTOR Signaling in Endometrial Carcinoma.
Academic Article Combined MEK and BCL-2/XL Inhibition Is Effective in High-Grade Serous Ovarian Cancer Patient-Derived Xenograft Models and BIM Levels Are Predictive of Responsiveness.
Academic Article AKT isoform-specific expression and activation across cancer lineages.
Academic Article Protein Kinase C Quality Control by Phosphatase PHLPP1?Unveils Loss-of-Function Mechanism in Cancer.
Academic Article GPNMB augments Wnt-1 mediated breast tumor initiation and growth by enhancing PI3K/AKT/mTOR pathway signaling and ?-catenin activity.
Concept Protein Kinase C beta
Academic Article Sequential Therapy with PARP and WEE1 Inhibitors Minimizes Toxicity while Maintaining Efficacy.
Academic Article Phase II trial of AKT inhibitor MK-2206 in patients with advanced breast cancer who have tumors with PIK3CA or AKT mutations, and/or PTEN loss/PTEN mutation.
Academic Article Safety lead-in of the MEK inhibitor trametinib in combination with GSK2141795, an AKT inhibitor, in patients with recurrent endometrial cancer: An NRG Oncology/GOG study.
Academic Article MCP-1/CCR-2 axis in adipocytes and cancer cell respectively facilitates ovarian cancer peritoneal metastasis.
Academic Article Genetic Alterations in the PI3K/AKT Pathway and Baseline AKT Activity Define AKT Inhibitor Sensitivity in Breast Cancer Patient-derived Xenografts.
Academic Article p85? regulates autophagic degradation of AXL to activate oncogenic signaling.
Academic Article Fibroblast-tumor cell signaling limits HER2 kinase therapy response via activation of MTOR and antiapoptotic pathways.
Academic Article Combining PARP with ATR inhibition overcomes PARP inhibitor and platinum resistance in ovarian cancer models.
Academic Article Targeting Extracellular Matrix Remodeling Restores BRAF Inhibitor Sensitivity in BRAFi-resistant Melanoma.
Academic Article Phase 2 study of buparlisib (BKM120), a pan-class I PI3K inhibitor, in patients with metastatic triple-negative breast cancer.
Academic Article MEK Inhibition Remodels the Immune Landscape of Mutant KRAS Tumors to Overcome Resistance to PARP and Immune Checkpoint Inhibitors.
Academic Article Landscapes of cellular phenotypic diversity in breast cancer xenografts and their impact on drug response.
Academic Article TOP1 modulation during melanoma progression and in adaptative resistance to BRAF and MEK inhibitors.
Academic Article Characterization of anticancer drug resistance by reverse-phase protein array: new targets and strategies.
Academic Article Identification of a Molecularly-Defined Subset of Breast and Ovarian Cancer Models that Respond to WEE1 or ATR Inhibition, Overcoming PARP Inhibitor Resistance.
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  • Proto Oncogene Proteins c akt